Publications - T. Leinders-Zufall

(OMIM search: link; PubMed search: link; NCIB nucleotide: link; ORCID link)


Complete list of publications:

My NCBI collection  –  ORCID: link  –  Google Scholar: link  – ResearchGate: link



Bufe B, Teuchert Y, Schmid A, Pyrski M, Pérez-Gómez A, Eisenbein J, Timm, T, Ishii T, Lochnit G, Bischoff M, Mombaerts P, Leinders-Zufall T & Zufall F. (2019) Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour .  Nature Communications 10, 4889


Blum T, Moreno-Pérez A, Pyrski M, Bufe B, Arifovic A, Weissgerber P, Freichel M, Zufall F, Leinders-Zufall T (2019) Trpc5 deficieny causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5135-5143 


Trouillet AC, Keller M, Weiss J, Leinders-Zufall T, Birnbaumer L, Zufall F, Chamero P (2019) Central role of G Protein Gai2 and Gai2+ vomeronasal Neurons in balancing territorial and Infant-directed aggression of male mice. Proc Natl Acad Sci USA 116, 5135-5143 



Münch J, Billig G, Huebner CA, Leinders-Zufall T, Zufall F, Jentsch TJ (2018) Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression. J Biol Chem 


Leinders-Zufall T, Storch U, Bleymehl K, Mederos y Schnitzler M, Frank JA, Konrad DB, Trauner D, Gudermann T, Zufall F (2018) PhoDAGs enable optical control of diacylglycerol-sensitive transient receptor potential channels. Cell Chemical Biology



Chamero, P, Weiss J, Alonso MT, Rodriguez-Prados M, Hisatsune C, Mikoshiba K, Leinders-Zufall T, Zufall F (2017) Type 3 inositiol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronsal organ. Scientific Reports 7(1):10260


Ma M, Leinders-Zufall T (2017) Olfactory sensory neurons of the peripheral olfactory system. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, pp.1-7. ISBN 9780128093245.


Leinders-Zufall T (2017) The accessory olfactory system. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, pp.1-8. ISBN 9780128093245.



Bleymehl K, Pérez-Gómez A, Omura M, Moreno-Pérez A, Macias D, Bai Z, Johnson RS, Leinders-Zufall T, Zufall F, Mombaerts P (2016) A sensor for low environmental oxygen in the mouse main olfactory epithelium. Neuron 92, 1-8.


Stein B, Alonso MT, Zufall F, Leinders-Zufall T, Chamero P (2016) Funtional overexpression of vomeronasal receptors using a Herpes Simplex Virus type 1 (HSV-1)-derived amplicon. PLoS One 11, e0156092 PMID: 27195771

Stempel H, Jung M, Pérez-Gómez A, Leinders-Zufall T, Zufall F, Bufe B (2016) Strain-specific loss of formyl peptide receptor 3 in the murine vomeronasal and immune systems. J Biol Chem 291, 9762-9775. PMID: 26957543

Bakker J, Leinders-Zufall T (2016) The sense of smell: the role of the olfactory systems in the detection of pheromones. In: Neuroscience in the 21st Century: From Basic to Clinical, Pfaff D.W. & Volkow N.D. (eds.), Springer, pp. 1-26.

Leinders-Zufall T, Chamero P (2016) cGMP signaling in olfactory sensory neurons. In: Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli, Zufall F & Munger S.D. (eds.), Elsevier, pp. 141-155.

Oboti L, Ibarra-Soria X, Pérez-Gómez A, Schmid A, Pyrski M, Paschek N, Kircher S, Logan DW, Leinders-Zufall T, Zufall F, Chamero P. (2015) Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium. BMC Biol 13:104. PMID: 26621367

Schauer C, Tong T, Petitjean H, Blum T, Peron S, Mai O, Schmitz F, Boehm U, Leinders-Zufall (2015) Hypothalamic gonadotropin releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol, epub, PMID: 26063780

Pérez-Gómez A, Bleymehl K, Stein B, Pyrski M, Birnbaumer L, Munger SD, Leinders-Zufall T, Zufall F, Chamero P (2015) Innate predator odor aversion driven by parallel olfactory subsystems that converge in the ventromedial hypothalamus. Current Biology 25, 11340. PMID: 25936549

Pérez-Gómez A, Stein B, Leinders-Zufall T, Chamero P (2014) Signalling mechanisms and behavioral function of the mouse basal vomeronasal neuroepithelium. Front Neuroanat 8, 135. PMID: 25505388

Oboti L, Pérez-Gómez A, Keller M, Jacobi E, Birnbaumer L, Leinders-Zufall T, Zufall F, Chamero P (2014) A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gao. BMC Biology 12, 31. PMID: 24886577

Leinders-Zufall T, Ishii T, Chamero P, Hendrix P, Oboti L, Schmid A, Kircher S, Pyrski M, Akiyoshi S, Khan M, Vaes E, Zufall F, Mombaerts P (2014) A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. J Neurosci 34: 5121-5133. PMID: 24719092

Leinders-Zufall T, Boehm U (2014) TRP channels in reproductive (neuro)endocrinology. Handbook of Experimental Pharmacology: Mammalian Transient Receptor Potential (TRP) Cation Channels, eds Nilius B & Flockerzi V (Springer), Vol 223: 1107-1118. PMID: 24961982

Leinders-Zufall T, Zufall F (2013) The electrovomeronasogram: field potential recordings in the mouse vomeronasal organ. Methods Mol Biol 1068: 221-236. PMID:24014365

Sturm T, Leinders-Zufall T, Macek B, Walzer M, Jung S, Pömmerl B Stevanovic S, Zufall F, Overath P, Rammensee HG. (2013) Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons. Nature Communications 4, 1616.

Chamero P, Leinders-Zufall T, Zufall F. (2012) From genes to social communication: molecular sensing by the vomeronasal organ. Trends Neurosci 35(10):597-606. PMID:22658923

Schauer C, Leinders-Zufall (2012) Imaging calicum responses in GFP-tagged neurons of hypothalamic mouse brain slices. J. Vis. Exp. (66), e4213, doi: 10.3791/4213.

Zufall F, Pyrski M, Weiss J, Leinders-Zufall T (2012) Link between pain and olfaction in an inherited sodium channelopathy. Arch Neurol (JAMA Neurology), 69(9): 1119-23. PMID:22733046

Oboti L, Schellino R, Giachino C, Chamero P, Pyrski M, Leinders-Zufall T, Zufall F, Fasolo A, Peretto P. Newborn interneurons in the accessory olfactory bulb promote mate recognition in female mice. Front Neurosci 2011, 5:113, PMID: 21994486

Chamero P, Katsoulidou V, Hendrix P, Bufe B, Roberts R, Matsunami H, Abramowitz J, Birnbaumer L, Zufall F, Leinders-Zufall T. G protein Gao is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci USA 2011, 108(31): 12898-12903, PMID: 21768373

Weiss J, Pyrski M, Jacobi E, Bufe B, Willnecker V, Schick B, Zizzari P, Gossage SJ, Greer CA, Leinders-Zufall T, Woods CG, Wood JN, Zufall F. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature. 2011 Apr 14;472(7342):186-90, DOI:10.1038/nature09975

Wen S, Götze IN, Mai O, Schauer C, Leinders-Zufall T, Boehm U. Genetic identification of GnRH receptor neurons: a new model for studying neural circuits underlying reproductive physiology in the mouse brain. Endocrinology 2011, 152(4): 1515-1526. PMID 21303944

Munger SD, Leinders-Zufall T, McDougall LM, Cockerham RE, Schmid A, Wandernoth P, Wennemuth G, Biel M, Zufall F, Kelliher KR. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol 2010, 20 (16): 1438-1444. 10.1016/j.cub.2010.06.021.

Schmid A, Pyrski M, Biel M, Leinders-Zufall T, Zufall F. Grueneberg ganglion neurons are finely tuned cold sensors. J Neurosci 2010 Jun 2; 30(22):7563-8. PMID: 20519530

Leinders-Zufall T, Ishii T, Mombaerts P, Zufall F, Boehm T. Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat Neurosci 2009 Dec;12(12):1551-8. PMID: 19935653

Cockerham RE, Leinders-Zufall T, Munger SD, Zufall F. Functional analysis of the guanylyl cyclase type D signaling system in the olfactory epithelium. Ann N Y Acad Sci. 2009 Jul;1170:173-6. PMID: 19686132

Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders-Zufall T, Zufall F. Ca2+-calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. J Neurosci 2009 Feb 18;29(7):2125-35. PMID: 19228965

Kwon HJ, Koo JH, Zufall F, Leinders-Zufall T, Margolis FL. Ca2+ extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 2009; 4(1):e4260. PMID: 19165324

Munger SD, Leinders-Zufall T, Zufall F. Subsystem organization of the mammalian sense of smell. Ann Rev Physiol 2009; 71: 115-140. PMID: 18808328.

Leinders-Zufall T, Zufall F (2009) Vomeronasal  accessory system. In: Encyclopedia of Neuroscience, 4th edition.  Squire L, Albright T, Bloom F, Gage F, Spitzer N (eds).,  pp. 453-459, Elsevier Science, Amsterdam.

Leinders-Zufall T, Ma M (2009) Olfaction epithelium. In: Encyclopedia of Neuroscience, 4th edition.  Squire L, Albright T, Bloom F, Gage F, Spitzer N (eds).,  pp. 113-118,  Elsevier Science, Amsterdam.

Zufall F, Leinders-Zufall T. Pheromonal communication in mice: from gene to behaviour. Neuroforum 2008; 14, 159-164.

Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F, Munger SD. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14507-12. PMID: 17724338

Ukhanov K, Leinders-Zufall T, Zufall F. Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined V1r or V2r receptor: ionic mechanisms underlying persistent firing. J Neurophysiol. 2007 Oct;98(4):2357-69. PMID: 17715188

Zufall F, Leinders-Zufall T. Mammalian pheromone sensing. Curr Opin Neurobiol. 2007 Aug;17(4):483-9. PMID: 17709238

Zufall F, Leinders-Zufall T, Puche AC (2007) Accessory olfactory system, In: The Senses: A Comprehensive Reference: Volume 4, Firestein S, Smith DV (eds), Elsevier Science, Amsterdam

Kelliher KR, Spehr M, Li XH, Zufall F, Leinders-Zufall T. Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur J Neurosci. 2006 Jun;23(12):3385-90. PMID: 16820028

Spehr M, Spehr J, Ukhanov K, Kelliher KR, Leinders-Zufall T, Zufall F. Parallel processing of social signals by the mammalian main and accessory olfactory systems. Cell Mol Life Sci. 2006 Jul;63(13):1476-84. PMID: 16732428

Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F. Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands. J Neurosci. 2006 Feb 15;26(7):1961-70. PMID: 16481428

Zufall F, Ukhanov K, Lucas P, Liman ER, Leinders-Zufall T. Neurobiology of TRPC2: from gene to behavior. Pflugers Arch. 2005 Oct;451(1):61-71.PMID: 15971083

Spehr M, Leinders-Zufall T. One neuron – multiple receptors: increased complexity in olfactory coding?
Science STKE. 2005 May 24;2005(285):pe25. STKE.pdf

Leinders-Zufall T, Brennan P, Widmayer P, S PC, Maul-Pavicic A, Jäger M, Li XH, Breer H, Zufall F, Boehm T. MHC class I peptides as chemosensory signals in the vomeronasal organ. Science. 2004 Nov 5;306(5698):1033-7. PMID: 15528444

Zufall F, Leinders-Zufall T (2004) Odor and pheromone transduction. In: Encyclopedia of Neuroscience, 3rd edition.  Eds. G. Adelman and B. H. Smith.  Elsevier Science, Amsterdam.

Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction.,Neuron. 2003 Oct 30;40(3):551-61. PMID: 14642279

Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, Ogawa S, Zufall F, Mombaerts P. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature. 2002 Sep 5;419(6902):70-4. PMID: 12214233

Vijverberg HPM, Leinders-Zufall T, Westerink RHS (2002) Multiple, distinct actions of metal ions on cellular signaling processes. Materialwissenschaft und Wirkstofftechnik 33, 751-755.

Zufall F, Kelliher KR, Leinders-Zufall T. Pheromone detection by mammalian vomeronasal neurons.
Microsc Res Tech. 2002 Aug 1;58(3):251-60. PMID: 12203702

Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R. Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6376-81. PMID: 11972034


Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau KW, Zufall F, Reed RR. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001 Dec 7;294(5549):2172-5. PMID: 11739959

Zufall F, Leinders-Zufall T. The cellular and molecular basis of odor adaptation.
Chem Senses. 2000 Aug;25(4):473-81. PMID: 10944513

Chen S, Lane AP, Bock R, Leinders-Zufall T, Zufall F. Blocking adenylyl cyclase inhibits olfactory generator currents induced by "IP(3)-odors". J Neurophysiol. 2000 Jul;84(1):575-80. PMID: 10899229

Leinders-Zufall T, Lane AP, Puche AC, Ma W, Novotny MV, Shipley MT, Zufall F. Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature. 2000 Jun 15;405(6788):792-6.  PMID: 10866200

Kafitz KW, Leinders-Zufall T, Zufall F, Greer CA. Cyclic GMP evoked calcium transients in olfactory receptor cell growth cones. Neuroreport. 2000 Mar 20;11(4):677-81. PMID: 10757499

Zufall F, Leinders-Zufall T, Greer CA. Amplification of odor-induced Ca(2+) transients by store-operated Ca(2+) release and its role in olfactory signal transduction. J Neurophysiol. 2000 Jan;83(1):501-12. PMID: 10634891

Leinders-Zufall T, Ma M, Zufall F. Impaired odor adaptation in olfactory receptor neurons after inhibition of Ca2+/calmodulin kinase II. J Neurosci. 1999 Jul 15;19(14):RC19. PMID: 10407061

Zufall F, Leinders-Zufall T (1999) Calcium imaging in the olfactory system: New tools for visualizing odor recognition. The Neuroscientist 5, 4-7.

Leinders-Zufall T, Richerson G (1999) Perforated patch-clamp technique. In: Electrophysiological Methods for the Study of the Mammalian Nervous System. JD Kocsis (ed), Appleton and Lange, (ISBN 0838563244).

Leinders-Zufall T (1999) Regulating the perfusion speed and height of microscope-mounted recording chambers.  In: Electrophysiological Methods for the Study of the Mammalian Nervous System.  JD Kocsis (ed), Appleton & Lange, (ISBN 0838563244).

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F. Visualizing odor detection in olfactory cilia by calcium imaging. Ann N Y Acad Sci. 1998 Nov 30;855:205-7. PMID: 9929606

Zufall F, Leinders-Zufall T. Role of cyclic GMP in olfactory transduction and adaptation.
Ann N Y Acad Sci. 1998 Nov 30;855:199-204. PMID: 9929605

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F. Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction. J Neurosci. 1998 Aug 1;18(15):5630-9. PMID: 9671654

Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA, Zufall F. Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci. 1997 Jun 1;17(11):4136-48. PMID: 9151731

Zufall F, Leinders-Zufall T (1997) Olfactory Transduction. In: Encyclopedia of Neuroscience, 2nd edition (CD ROM), Adelman G and Smith BH (eds), Elsevier, Amsterdam, The Netherlands.

Zufall F, Leinders-Zufall T. (1997) Identification of a long-lasting form of odor adaptation that depends on the carbon Monoxide/cGMP second-messenger system. J Neurosci. 1997 Apr 15;17(8):2703-12. PMID: 9092591

Leinders-Zufall T, Shepherd GM, Zufall F. Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells. Proc Biol Sci. 1996 Jun 22;263(1371):803-11. PMID: 8763798

Leinders-Zufall T, Zufall F. Block of cyclic nucleotide-gated channels in salamander olfactory receptor neurons by the guanylyl cyclase inhibitor LY83583. J Neurophysiol. 1995 Dec;74(6):2759-62. PMID: 8747232

Leinders-Zufall T, Shepherd GM, Zufall F. Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol. 1995 Oct;74(4):1498-508. PMID: 8989388

Leinders-Zufall T, Rosenboom H, Barnstable CJ, Shepherd GM, Zufall F. A calcium-permeable cGMP-activated cation conductance in hippocampal neurons. Neuroreport. 1995 Sep 11;6(13):1761-5. PMID: 8541476

van den Bercken J, Oortgiesen M, Leinders T, Vijverberg HPM (1995)  In vitro electrophysiological studies in neurotoxicology. In: Neurotoxicology, Approaches and Methods, Chang L.W. & Slikker W. eds., Marcel Dekker, New York.

Vijverberg HPM, Oortgiesen M, Leinders-Zufall T, Zwart R (1995) Neurotoxicity in vitro: Cultured neuronal cell lines and electrophysiological approach. In: Modulation of Cellular Responses in Toxicity, Galli C.L. ed., NATO Advanced Study Institute, Springer Verlag, Berlin.

Vijverberg HP, Leinders-Zufall T, van Kleef RG. Differential effects of heavy metal ions on Ca(2+)-dependent K+ channels. Cell Mol Neurobiol. 1994 Dec;14(6):841-57. PMID: 7641241

Leinders-Zufall T, Rand MN, Waxman SG, Kocsis JD. Differential role of two Ca(2+)-permeable non-NMDA glutamate channels in rat retinal ganglion cells: kainate-induced cytoplasmic and nuclear Ca2+ signals. J Neurophysiol. 1994 Nov;72(5):2503-16. PMID: 7884475

Rand MN, Leinders-Zufall T, Agulian S, Kocsis JD. Calcium signals in neurons. Nature. 1994 Sep 22;371(6495):291-2. PMID: 8090198

Vijverberg HP, Oortgiesen M, Leinders T, van Kleef RG. Metal interactions with voltage- and receptor-activated ion channels. Environ Health Perspect. 1994 Sep;102 Suppl 3:153-8. PMID: 7531139

Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan;12(1):155-65. PMID: 7507337

Oortgiesen M, Leinders T, van Kleef RG, Vijverberg HP. Differential neurotoxicological effects of lead on voltage-dependent and receptor-operated ion channels. Neurotoxicology. 1993 Summer-Fall;14(2-3):87-96. PMID: 7504228

van den Bercken J, Oortgiesen M, Leinders T, Vijverberg HPM (1993)  Electrophysiolocial approaches to in vitro neurotoxicology. In: Alternative Methods in Toxicology, Vol. 9, Goldberg A.M. (ed), Mary Ann Liebert Inc., New York.

Leinders T, Vijverberg HP. Ca2+ dependence of small Ca(2+)-activated K+ channels in cultured N1E-115 mouse neuroblastoma cells. Pflugers Arch. 1992 Dec;422(3):223-32. PMID: 1488280

Leinders T, van Kleef RG, Vijverberg HP. Divalent cations activate small- (SK) and large-conductance (BK) channels in mouse neuroblastoma cells: selective activation of SK channels by cadmium. Pflugers Arch. 1992 Dec;422(3):217-22. PMID: 1488279

Leinders T, van Kleef RG, Vijverberg HP. Distinct metal ion binding sites on Ca(2+)-activated K+ channels in inside-out patches of human erythrocytes. Biochim Biophys Acta. 1992 Nov 23;1112(1):75-82. PMID: 1420273

Leinders T, van Kleef RG, Vijverberg HP. Single Ca(2+)-activated K+ channels in human erythrocytes: Ca2+ dependence of opening frequency but not of open lifetimes. Biochim Biophys Acta. 1992 Nov 23;1112(1):67-74. PMID: 1420271

de Weille JR, Leinders T. The action of pyrethroids on sodium channels in myelinated nerve fibres and spinal ganglion cells of the frog. Brain Res. 1989 Mar 20;482(2):324-32. PMID: 2539885

Tonnaer JA, Leinders T, van Delft AM. Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1 and D2 receptors in rat striatum. Psychoneuroendocrinology. 1989;14(6):469-76. PMID: 2533695