Publications - T. Leinders-Zufall

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Complete list of publications:

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2020

Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Overwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermans S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W (2020)  Chemosensory cell-derived acetylcholine drives tracheal mucociliary clearance in response to virulence-associated formyl peptides. Immunity 52, 683.

 

2019

Bufe B, Teuchert Y, Schmid A, Pyrski M, Pérez-Gómez A, Eisenbein J, Timm, T, Ishii T, Lochnit G, Bischoff M, Mombaerts P, Leinders-Zufall T & Zufall F. (2019) Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour .  Nature Communications 10, 4889

 

Blum T, Moreno-Pérez A, Pyrski M, Bufe B, Arifovic A, Weissgerber P, Freichel M, Zufall F, Leinders-Zufall T (2019) Trpc5 deficieny causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5135-5143 

 

Trouillet AC, Keller M, Weiss J, Leinders-Zufall T, Birnbaumer L, Zufall F, Chamero P (2019) Central role of G Protein Gai2 and Gai2+ vomeronasal Neurons in balancing territorial and Infant-directed aggression of male mice. Proc Natl Acad Sci USA 116, 5135-5143 

 

2018

Münch J, Billig G, Huebner CA, Leinders-Zufall T, Zufall F, Jentsch TJ (2018) Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression. J Biol Chem 

 

Leinders-Zufall T, Storch U, Bleymehl K, Mederos y Schnitzler M, Frank JA, Konrad DB, Trauner D, Gudermann T, Zufall F (2018) PhoDAGs enable optical control of diacylglycerol-sensitive transient receptor potential channels. Cell Chemical Biology

 

2017

Chamero, P, Weiss J, Alonso MT, Rodriguez-Prados M, Hisatsune C, Mikoshiba K, Leinders-Zufall T, Zufall F (2017) Type 3 inositiol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronsal organ. Scientific Reports 7(1):10260

 

Ma M, Leinders-Zufall T (2017) Olfactory sensory neurons of the peripheral olfactory system. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, pp.1-7. ISBN 9780128093245. http://dx.doi.org/10.1016/B978-0-12-809324-5.02899-6

 

Leinders-Zufall T (2017) The accessory olfactory system. Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, pp.1-8. ISBN 9780128093245. http://dx.doi.org/10.1016/B978-0-12-809324-5.02909-6

 

2016

Bleymehl K, Pérez-Gómez A, Omura M, Moreno-Pérez A, Macias D, Bai Z, Johnson RS, Leinders-Zufall T, Zufall F, Mombaerts P (2016) A sensor for low environmental oxygen in the mouse main olfactory epithelium. Neuron 92, 1-8.

 

Stein B, Alonso MT, Zufall F, Leinders-Zufall T, Chamero P (2016) Funtional overexpression of vomeronasal receptors using a Herpes Simplex Virus type 1 (HSV-1)-derived amplicon. PLoS One 11, e0156092 PMID: 27195771


Stempel H, Jung M, Pérez-Gómez A, Leinders-Zufall T, Zufall F, Bufe B (2016) Strain-specific loss of formyl peptide receptor 3 in the murine vomeronasal and immune systems. J Biol Chem 291, 9762-9775. PMID: 26957543

Bakker J, Leinders-Zufall T (2016) The sense of smell: the role of the olfactory systems in the detection of pheromones. In: Neuroscience in the 21st Century: From Basic to Clinical, Pfaff D.W. & Volkow N.D. (eds.), Springer, pp. 1-26.

Leinders-Zufall T, Chamero P (2016) cGMP signaling in olfactory sensory neurons. In: Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli, Zufall F & Munger S.D. (eds.), Elsevier, pp. 141-155.

2015
Oboti L, Ibarra-Soria X, Pérez-Gómez A, Schmid A, Pyrski M, Paschek N, Kircher S, Logan DW, Leinders-Zufall T, Zufall F, Chamero P. (2015) Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium. BMC Biol 13:104. PMID: 26621367

Schauer C, Tong T, Petitjean H, Blum T, Peron S, Mai O, Schmitz F, Boehm U, Leinders-Zufall (2015) Hypothalamic gonadotropin releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol, epub, PMID: 26063780

Pérez-Gómez A, Bleymehl K, Stein B, Pyrski M, Birnbaumer L, Munger SD, Leinders-Zufall T, Zufall F, Chamero P (2015) Innate predator odor aversion driven by parallel olfactory subsystems that converge in the ventromedial hypothalamus. Current Biology 25, 11340. PMID: 25936549

2014
Pérez-Gómez A, Stein B, Leinders-Zufall T, Chamero P (2014) Signalling mechanisms and behavioral function of the mouse basal vomeronasal neuroepithelium. Front Neuroanat 8, 135. PMID: 25505388

Oboti L, Pérez-Gómez A, Keller M, Jacobi E, Birnbaumer L, Leinders-Zufall T, Zufall F, Chamero P (2014) A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gao. BMC Biology 12, 31. PMID: 24886577

Leinders-Zufall T, Ishii T, Chamero P, Hendrix P, Oboti L, Schmid A, Kircher S, Pyrski M, Akiyoshi S, Khan M, Vaes E, Zufall F, Mombaerts P (2014) A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. J Neurosci 34: 5121-5133. PMID: 24719092

Leinders-Zufall T, Boehm U (2014) TRP channels in reproductive (neuro)endocrinology. Handbook of Experimental Pharmacology: Mammalian Transient Receptor Potential (TRP) Cation Channels, eds Nilius B & Flockerzi V (Springer), Vol 223: 1107-1118. PMID: 24961982

2013
Leinders-Zufall T, Zufall F (2013) The electrovomeronasogram: field potential recordings in the mouse vomeronasal organ. Methods Mol Biol 1068: 221-236. PMID:24014365

Sturm T, Leinders-Zufall T, Macek B, Walzer M, Jung S, Pömmerl B Stevanovic S, Zufall F, Overath P, Rammensee HG. (2013) Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons. Nature Communications 4, 1616.

2012
Chamero P, Leinders-Zufall T, Zufall F. (2012) From genes to social communication: molecular sensing by the vomeronasal organ. Trends Neurosci 35(10):597-606. PMID:22658923

Schauer C, Leinders-Zufall (2012) Imaging calicum responses in GFP-tagged neurons of hypothalamic mouse brain slices. J. Vis. Exp. (66), e4213, doi: 10.3791/4213.

Zufall F, Pyrski M, Weiss J, Leinders-Zufall T (2012) Link between pain and olfaction in an inherited sodium channelopathy. Arch Neurol (JAMA Neurology), 69(9): 1119-23. PMID:22733046

2011
Oboti L, Schellino R, Giachino C, Chamero P, Pyrski M, Leinders-Zufall T, Zufall F, Fasolo A, Peretto P. Newborn interneurons in the accessory olfactory bulb promote mate recognition in female mice. Front Neurosci 2011, 5:113, PMID: 21994486

Chamero P, Katsoulidou V, Hendrix P, Bufe B, Roberts R, Matsunami H, Abramowitz J, Birnbaumer L, Zufall F, Leinders-Zufall T. G protein Gao is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci USA 2011, 108(31): 12898-12903, PMID: 21768373

Weiss J, Pyrski M, Jacobi E, Bufe B, Willnecker V, Schick B, Zizzari P, Gossage SJ, Greer CA, Leinders-Zufall T, Woods CG, Wood JN, Zufall F. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature. 2011 Apr 14;472(7342):186-90, DOI:10.1038/nature09975

Wen S, Götze IN, Mai O, Schauer C, Leinders-Zufall T, Boehm U. Genetic identification of GnRH receptor neurons: a new model for studying neural circuits underlying reproductive physiology in the mouse brain. Endocrinology 2011, 152(4): 1515-1526. PMID 21303944

2010
Munger SD, Leinders-Zufall T, McDougall LM, Cockerham RE, Schmid A, Wandernoth P, Wennemuth G, Biel M, Zufall F, Kelliher KR. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol 2010, 20 (16): 1438-1444. 10.1016/j.cub.2010.06.021.

Schmid A, Pyrski M, Biel M, Leinders-Zufall T, Zufall F. Grueneberg ganglion neurons are finely tuned cold sensors. J Neurosci 2010 Jun 2; 30(22):7563-8. PMID: 20519530

2009
Leinders-Zufall T, Ishii T, Mombaerts P, Zufall F, Boehm T. Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat Neurosci 2009 Dec;12(12):1551-8. PMID: 19935653

Cockerham RE, Leinders-Zufall T, Munger SD, Zufall F. Functional analysis of the guanylyl cyclase type D signaling system in the olfactory epithelium. Ann N Y Acad Sci. 2009 Jul;1170:173-6. PMID: 19686132

Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders-Zufall T, Zufall F. Ca2+-calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. J Neurosci 2009 Feb 18;29(7):2125-35. PMID: 19228965

Kwon HJ, Koo JH, Zufall F, Leinders-Zufall T, Margolis FL. Ca2+ extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 2009; 4(1):e4260. PMID: 19165324

Munger SD, Leinders-Zufall T, Zufall F. Subsystem organization of the mammalian sense of smell. Ann Rev Physiol 2009; 71: 115-140. PMID: 18808328.

Leinders-Zufall T, Zufall F (2009) Vomeronasal  accessory system. In: Encyclopedia of Neuroscience, 4th edition.  Squire L, Albright T, Bloom F, Gage F, Spitzer N (eds).,  pp. 453-459, Elsevier Science, Amsterdam.

Leinders-Zufall T, Ma M (2009) Olfaction epithelium. In: Encyclopedia of Neuroscience, 4th edition.  Squire L, Albright T, Bloom F, Gage F, Spitzer N (eds).,  pp. 113-118,  Elsevier Science, Amsterdam.

2008
Zufall F, Leinders-Zufall T. Pheromonal communication in mice: from gene to behaviour. Neuroforum 2008; 14, 159-164.

2007
Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F, Munger SD. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14507-12. PMID: 17724338

Ukhanov K, Leinders-Zufall T, Zufall F. Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined V1r or V2r receptor: ionic mechanisms underlying persistent firing. J Neurophysiol. 2007 Oct;98(4):2357-69. PMID: 17715188

Zufall F, Leinders-Zufall T. Mammalian pheromone sensing. Curr Opin Neurobiol. 2007 Aug;17(4):483-9. PMID: 17709238

Zufall F, Leinders-Zufall T, Puche AC (2007) Accessory olfactory system, In: The Senses: A Comprehensive Reference: Volume 4, Firestein S, Smith DV (eds), Elsevier Science, Amsterdam

2006
Kelliher KR, Spehr M, Li XH, Zufall F, Leinders-Zufall T. Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur J Neurosci. 2006 Jun;23(12):3385-90. PMID: 16820028

Spehr M, Spehr J, Ukhanov K, Kelliher KR, Leinders-Zufall T, Zufall F. Parallel processing of social signals by the mammalian main and accessory olfactory systems. Cell Mol Life Sci. 2006 Jul;63(13):1476-84. PMID: 16732428

Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F. Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands. J Neurosci. 2006 Feb 15;26(7):1961-70. PMID: 16481428

2005
Zufall F, Ukhanov K, Lucas P, Liman ER, Leinders-Zufall T. Neurobiology of TRPC2: from gene to behavior. Pflugers Arch. 2005 Oct;451(1):61-71.PMID: 15971083

Spehr M, Leinders-Zufall T. One neuron – multiple receptors: increased complexity in olfactory coding?
Science STKE. 2005 May 24;2005(285):pe25. STKE.pdf

2004
Leinders-Zufall T, Brennan P, Widmayer P, S PC, Maul-Pavicic A, Jäger M, Li XH, Breer H, Zufall F, Boehm T. MHC class I peptides as chemosensory signals in the vomeronasal organ. Science. 2004 Nov 5;306(5698):1033-7. PMID: 15528444

Zufall F, Leinders-Zufall T (2004) Odor and pheromone transduction. In: Encyclopedia of Neuroscience, 3rd edition.  Eds. G. Adelman and B. H. Smith.  Elsevier Science, Amsterdam.

2003
Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction.,Neuron. 2003 Oct 30;40(3):551-61. PMID: 14642279

2002
Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, Ogawa S, Zufall F, Mombaerts P. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature. 2002 Sep 5;419(6902):70-4. PMID: 12214233

Vijverberg HPM, Leinders-Zufall T, Westerink RHS (2002) Multiple, distinct actions of metal ions on cellular signaling processes. Materialwissenschaft und Wirkstofftechnik 33, 751-755.

Zufall F, Kelliher KR, Leinders-Zufall T. Pheromone detection by mammalian vomeronasal neurons.
Microsc Res Tech. 2002 Aug 1;58(3):251-60. PMID: 12203702

Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R. Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6376-81. PMID: 11972034

2001

Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau KW, Zufall F, Reed RR. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001 Dec 7;294(5549):2172-5. PMID: 11739959

2000
Zufall F, Leinders-Zufall T. The cellular and molecular basis of odor adaptation.
Chem Senses. 2000 Aug;25(4):473-81. PMID: 10944513

Chen S, Lane AP, Bock R, Leinders-Zufall T, Zufall F. Blocking adenylyl cyclase inhibits olfactory generator currents induced by "IP(3)-odors". J Neurophysiol. 2000 Jul;84(1):575-80. PMID: 10899229

Leinders-Zufall T, Lane AP, Puche AC, Ma W, Novotny MV, Shipley MT, Zufall F. Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature. 2000 Jun 15;405(6788):792-6.  PMID: 10866200

Kafitz KW, Leinders-Zufall T, Zufall F, Greer CA. Cyclic GMP evoked calcium transients in olfactory receptor cell growth cones. Neuroreport. 2000 Mar 20;11(4):677-81. PMID: 10757499

Zufall F, Leinders-Zufall T, Greer CA. Amplification of odor-induced Ca(2+) transients by store-operated Ca(2+) release and its role in olfactory signal transduction. J Neurophysiol. 2000 Jan;83(1):501-12. PMID: 10634891

1999
Leinders-Zufall T, Ma M, Zufall F. Impaired odor adaptation in olfactory receptor neurons after inhibition of Ca2+/calmodulin kinase II. J Neurosci. 1999 Jul 15;19(14):RC19. PMID: 10407061

Zufall F, Leinders-Zufall T (1999) Calcium imaging in the olfactory system: New tools for visualizing odor recognition. The Neuroscientist 5, 4-7.

Leinders-Zufall T, Richerson G (1999) Perforated patch-clamp technique. In: Electrophysiological Methods for the Study of the Mammalian Nervous System. JD Kocsis (ed), Appleton and Lange, (ISBN 0838563244).

Leinders-Zufall T (1999) Regulating the perfusion speed and height of microscope-mounted recording chambers.  In: Electrophysiological Methods for the Study of the Mammalian Nervous System.  JD Kocsis (ed), Appleton & Lange, (ISBN 0838563244).

1998
Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F. Visualizing odor detection in olfactory cilia by calcium imaging. Ann N Y Acad Sci. 1998 Nov 30;855:205-7. PMID: 9929606

Zufall F, Leinders-Zufall T. Role of cyclic GMP in olfactory transduction and adaptation.
Ann N Y Acad Sci. 1998 Nov 30;855:199-204. PMID: 9929605

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F. Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction. J Neurosci. 1998 Aug 1;18(15):5630-9. PMID: 9671654

1997
Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA, Zufall F. Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci. 1997 Jun 1;17(11):4136-48. PMID: 9151731

Zufall F, Leinders-Zufall T (1997) Olfactory Transduction. In: Encyclopedia of Neuroscience, 2nd edition (CD ROM), Adelman G and Smith BH (eds), Elsevier, Amsterdam, The Netherlands.

Zufall F, Leinders-Zufall T. (1997) Identification of a long-lasting form of odor adaptation that depends on the carbon Monoxide/cGMP second-messenger system. J Neurosci. 1997 Apr 15;17(8):2703-12. PMID: 9092591

1996
Leinders-Zufall T, Shepherd GM, Zufall F. Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells. Proc Biol Sci. 1996 Jun 22;263(1371):803-11. PMID: 8763798

1995
Leinders-Zufall T, Zufall F. Block of cyclic nucleotide-gated channels in salamander olfactory receptor neurons by the guanylyl cyclase inhibitor LY83583. J Neurophysiol. 1995 Dec;74(6):2759-62. PMID: 8747232

Leinders-Zufall T, Shepherd GM, Zufall F. Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol. 1995 Oct;74(4):1498-508. PMID: 8989388

Leinders-Zufall T, Rosenboom H, Barnstable CJ, Shepherd GM, Zufall F. A calcium-permeable cGMP-activated cation conductance in hippocampal neurons. Neuroreport. 1995 Sep 11;6(13):1761-5. PMID: 8541476

van den Bercken J, Oortgiesen M, Leinders T, Vijverberg HPM (1995)  In vitro electrophysiological studies in neurotoxicology. In: Neurotoxicology, Approaches and Methods, Chang L.W. & Slikker W. eds., Marcel Dekker, New York.

Vijverberg HPM, Oortgiesen M, Leinders-Zufall T, Zwart R (1995) Neurotoxicity in vitro: Cultured neuronal cell lines and electrophysiological approach. In: Modulation of Cellular Responses in Toxicity, Galli C.L. ed., NATO Advanced Study Institute, Springer Verlag, Berlin.

1994
Vijverberg HP, Leinders-Zufall T, van Kleef RG. Differential effects of heavy metal ions on Ca(2+)-dependent K+ channels. Cell Mol Neurobiol. 1994 Dec;14(6):841-57. PMID: 7641241

Leinders-Zufall T, Rand MN, Waxman SG, Kocsis JD. Differential role of two Ca(2+)-permeable non-NMDA glutamate channels in rat retinal ganglion cells: kainate-induced cytoplasmic and nuclear Ca2+ signals. J Neurophysiol. 1994 Nov;72(5):2503-16. PMID: 7884475

Rand MN, Leinders-Zufall T, Agulian S, Kocsis JD. Calcium signals in neurons. Nature. 1994 Sep 22;371(6495):291-2. PMID: 8090198

Vijverberg HP, Oortgiesen M, Leinders T, van Kleef RG. Metal interactions with voltage- and receptor-activated ion channels. Environ Health Perspect. 1994 Sep;102 Suppl 3:153-8. PMID: 7531139

Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan;12(1):155-65. PMID: 7507337

1993
Oortgiesen M, Leinders T, van Kleef RG, Vijverberg HP. Differential neurotoxicological effects of lead on voltage-dependent and receptor-operated ion channels. Neurotoxicology. 1993 Summer-Fall;14(2-3):87-96. PMID: 7504228

van den Bercken J, Oortgiesen M, Leinders T, Vijverberg HPM (1993)  Electrophysiolocial approaches to in vitro neurotoxicology. In: Alternative Methods in Toxicology, Vol. 9, Goldberg A.M. (ed), Mary Ann Liebert Inc., New York.

1992
Leinders T, Vijverberg HP. Ca2+ dependence of small Ca(2+)-activated K+ channels in cultured N1E-115 mouse neuroblastoma cells. Pflugers Arch. 1992 Dec;422(3):223-32. PMID: 1488280

Leinders T, van Kleef RG, Vijverberg HP. Divalent cations activate small- (SK) and large-conductance (BK) channels in mouse neuroblastoma cells: selective activation of SK channels by cadmium. Pflugers Arch. 1992 Dec;422(3):217-22. PMID: 1488279

Leinders T, van Kleef RG, Vijverberg HP. Distinct metal ion binding sites on Ca(2+)-activated K+ channels in inside-out patches of human erythrocytes. Biochim Biophys Acta. 1992 Nov 23;1112(1):75-82. PMID: 1420273

Leinders T, van Kleef RG, Vijverberg HP. Single Ca(2+)-activated K+ channels in human erythrocytes: Ca2+ dependence of opening frequency but not of open lifetimes. Biochim Biophys Acta. 1992 Nov 23;1112(1):67-74. PMID: 1420271

1989
de Weille JR, Leinders T. The action of pyrethroids on sodium channels in myelinated nerve fibres and spinal ganglion cells of the frog. Brain Res. 1989 Mar 20;482(2):324-32. PMID: 2539885

Tonnaer JA, Leinders T, van Delft AM. Ovariectomy and subchronic estradiol-17 beta administration decrease dopamine D1 and D2 receptors in rat striatum. Psychoneuroendocrinology. 1989;14(6):469-76. PMID: 2533695