Publications - F. Zufall

Chamero, P, Weiss J, Alonso MT, Rodriguez-Prados M, Hisatsune C, Mikoshiba K, Leinders-Zufall T, Zufall F (2017) Type 3 inositiol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronsal organ. Scientific Reports 7(1):10260

 

Bolz F, Kasper S, Bufe B, Zufall F, Pyrski M (2017) Organization and plasticity of sodium channel expression in the mouse olfactory and vomeronasal epithelia. Front. Neuroanat.

 

Pyrski M, Eckstein E, Schmid A, Bufe B, Weiss J, Chubanov V, Boehm U, Zufall F (2017) Trpm5 expression in the olfactory epithelium. Molecular & Cellular Neuroscience 80, 75-88.

 

Bleymehl K, Pérez-Gómez A, Omura M, Moreno-Pérez A, Macias D, Bai Z, Johnson RS, Leinders-Zufall T, Zufall F, Mombaerts P (2016) A sensor for low environmental oxygen in the mouse main olfactory epithelium. Neuron 92, 1-8. PMID:27916458

 

Stein B, Alonso MT, Zufall F, Leinders-Zufall T, Chamero P (2016) Funtional overexpression of vomeronasal receptors using a Herpes Simplex Virus type 1 (HSV-1)-derived amplicon. PLoS One 11, e0156092 PMID: 27195771

 

Stempel H, Jung M, Pérez-Gómez A, Leinders-Zufall T, Zufall F, Bufe B (2016) Strain-specific loss of formyl peptide receptor 3 in the murine vomeronasal and immune systems. J Biol Chem 291, 9762-9775. PMID: 26957543

 

Zufall F, Munger SD (2016) Chemosensory Transduction: The detection of odors, tastes, and other chemostimuli. 1st Edition, Elsevier.

 

Oboti L, Ibarra-Soria X, Perez-Gomez A, Schmid A, Pyrski M, Paschek N, Kircher S, Logan DW, Leinders-Zufall T, Zufall F, Chamero P. (2015) Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium. BMC Biol 13:104. PMID: 26621367

 

Kusumakshi S, Voigt A, Hübner S, Hermans-Borgmeyer I, Ortalli A, Pyrski M, Dörr J, Zufall F, Flockerzi V, Meyerhof W, Montmayeur JP, Boehm U (2015) A binary genetic approach to characterize TRPM5 cells in mice. Chem Senses 40:413-25 PMID: 25940069

 

Perez-Gomez A, Bleymehl K, Stein B, Pyrski M, Birnbaumer L, Munger SD, Leinders-Zufall T, Zufall F, Chamero P (2015) Innate predator odor aversion driven by parallel olfactory subsystems that converge in the ventromedial hypothalamus. Current Biol 25: 1340-1346. PMID: 25936549

 

Bufe B, Schumann T Kappl R, Bogeski I, Kummerow C, Podgorska M, Smola S, Hoth M, Zufall F (2015) Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens. J Biol Chem 290:7369-87. PMID: 25605714

 

Weiss J, Pyrski M, Weissgerber P, Zufall F (2014) Altered synaptic transmission at olfactory and vomeronasal nerve terminals in mice lacking N-type calcium cahnnel Cav2.2. Eur J Neurosci 40: 3422-35. PMID: 25195871

 

Zufall F (2014) TRPs in olfaction. Handbook of Experimental Pharmacology: Mammalian Transient Receptor Potential (TRP) Cation Channels, eds Nilius B & Flockerzi V (Springer), Vol 223: 917 - 933. PMID: 24961974

 

Leinders-Zufall T, Ishii T, Chamero P, Hendrix P, Oboti L, Schmid A, Kircher S, Pyrski M, Akiyoshi S, Khan M, Vaes E, Zufall F, Mombaerts P (2014) A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. J Neurosci 34: 5121-5133. PMID: 24719092

 

Kummerow C, Schwarz EC, Bufe B, Zufall F, Hoth M, Qu B (2014) A simple, economic, time-resolved killing assay. Eur J Immunol, epub. PMID: 24599783

 

Leinders-Zufall T, Zufall F (2013) The electrovomeronasogram: field potential recordings in the mouse vomeronasal organ. Methods Mol Biol 1068: 221-236. PMID:24014365

 

Arakawa H, Kelliher KR, Zufall F, Munger SD. (2013) The receptor guanylyl cyclase type D (GC-D) ligand uroguanylin promotes the acquisition of food preferences in mice. Chem. Senses 38, 391-197. PMID:23564012

 

Sturm T, Leinders-Zufall T, Macek B, Walzer M, Jung S, Pömmerl B Stevanovic S, Zufall F, Overath P, Rammensee HG. (2013) Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons. Nature Communications 4, 1616.

 

Bufe B, Schumann T, Zufall F. (2012) Formyl peptide receptors from immune and voermonasal system exhibit distinct agonist properties. J Biol Chem 2012, epub. PMID: 22859307

 

Zufall F, Pyrski M, Weiss J, Leinders-Zufall T (2012) Link between pain and olfaction in an inherited sodium channelopathy. Arch Neurol, doi: 10.1001/archneurol.2012.21. PMID:22733046

 

Chamero P, Leinders-Zufall T, Zufall F. From genes to social communication: molecular sensing by the vomeronasal organ. Trends Neurosci 2012 PMID:22658923

 

Zufall F. On the scent of mitochondrial calcium. Nature Neuroscience 2012, 15 (5): 653-654. doi:10.1038/nn.3090

 

Bautze V, Bär R, Fissler B, Trapp M, Schmidt D, Beifuss U, Bufe B, Zufall F, Breer H, Strotmann J. Mammalian-specific OR37 receptors are differentially activated by distinct odorous fatty aldehydes. Chem Senses. 2012 Jun;37(5):479-93. PMID: 22302156

 

Oboti L, Schellino R, Giachino C, Chamero P, Pyrski M, Leinders-Zufall T, Zufall F, Fasolo A, Peretto P. Newborn interneurons in the accessory olfactory bulb promote mate recognition in female mice. Front Neurosci 2011, 5:113, PMID: 21994486

 

Chamero P, Katsoulidou V, Hendrix P, Bufe B, Roberts R, Matsunami H, Abramowitz J, Birnbaumer L, Zufall F, Leinders-Zufall T. G protein Gao is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci USA 2011, 108(31): 12898-12903, PMID: 2176837

 

Weiss J, Pyrski M, Jacobi E, Bufe B, Willnecker V, Schick B, Zizzari P, Gossage SJ, Greer CA, Leinders-Zufall T, Woods CG, Wood JN, Zufall F. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature. 2011 Apr 14;472(7342):186-90, DOI:10.1038/nature09975

 

Munger SD, Leinders-Zufall T, McDougall LM, Cockerham RE, Schmid A, Wandernoth P, Wennemuth G, Biel M, Zufall F, Kelliher KR. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol 2010, 20 (16): 1438-1444. 10.1016/j.cub.2010.06.021.

 

Schmid A, Pyrski M, Biel M, Leinders-Zufall T, Zufall F. Grueneberg ganglion neurons are finely tuned cold sensors. J Neurosci 2010 Jun 2; 30(22):7563-8. PMID: 20519530

 

Zufall F, Munger SD. Receptor gunaylyl cyclases in mammalian olfactory function. Mol Cell Biochem 2009 Nov 26. PMID: 19941039

 

Leinders-Zufall T, Ishii T, Mombaerts P, Zufall F, Boehm T. Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat Neurosci 2009 Dec;12(12):1551-8. PMID: 19935653

 

Cockerham RE, Leinders-Zufall T, Munger SD, Zufall F. Functional analysis of the guanylyl cyclase type D signaling system in the olfactory epithelium. Ann N Y Acad Sci. 2009 Jul;1170:173-6. PMID: 19686132

 

Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders-Zufall T, Zufall F. Ca2+-calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. J Neurosci 2009 Feb 18;29(7):2125-35. PMID: 19228965

 

Kwon HJ, Koo JH, Zufall F, Leinders-Zufall T, Margolis FL. Ca2+ extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 2009; 4(1):e4260. PMID: 19165324

 

Munger SD, Leinders-Zufall T, Zufall F. Subsystem organization of the mammalian sense of smell. Ann Rev Physiol 2009; 71: 115-140. PMID: 18808328.

 

Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F, Munger SD. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14507-12. PMID: 17724338

 

Ukhanov K, Leinders-Zufall T, Zufall F. Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined V1r or V2r receptor: ionic mechanisms underlying persistent firing. J Neurophysiol. 2007 Oct;98(4):2357-69. PMID: 17715188

 

Zufall F, Leinders-Zufall T. Mammalian pheromone sensing. Curr Opin Neurobiol. 2007 Aug;17(4):483-9. PMID: 17709238

 

Brennan PA, Zufall F. Pheromonal communication in vertebrates. Nature. 2006 Nov 16;444(7117):308-15. PMID: 17108955

 

Zufall F, Leinders-Zufall T, Puche AC (2007) Accessory olfactory system, In: The Senses: A Comprehensive Reference: Volume 4, Firestein S, Smith DV (eds), Elsevier Science, Amsterdam

 

Leinders-Zufall T, Zufall F (2007) Vomeronasal accessory system. In: Encyclopedia of Neuroscience, 4th edition.  Squire L, Albright T, Bloom F, Gage F, Spitzer N (eds).  Elsevier Science, Amsterdam.

 

Kelliher KR, Spehr M, Li XH, Zufall F, Leinders-Zufall T. Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing. Eur J Neurosci. 2006 Jun;23(12):3385-90. PMID: 16820028

 

Spehr M, Spehr J, Ukhanov K, Kelliher KR, Leinders-Zufall T, Zufall F. Parallel processing of social signals by the mammalian main and accessory olfactory systems. Cell Mol Life Sci. 2006 Jul;63(13):1476-84. PMID: 16732428

 

Spehr M, Kelliher KR, Li XH, Boehm T, Leinders-Zufall T, Zufall F. Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands. J Neurosci. 2006 Feb 15;26(7):1961-70. PMID: 16481428

 

Boehm T, Zufall F. MHC peptides and the sensory evaluation of genotype. Trends Neurosci. 2006 Feb;29(2):100-7. PMID: 16337283

 

Zufall F, Ukhanov K, Lucas P, Liman ER, Leinders-Zufall T. Neurobiology of TRPC2: from gene to behavior. Pflugers Arch. 2005 Oct;451(1):61-71.PMID: 15971083

 

Zufall F. Connexins and olfactory synchronicity: toward the olfactory code. Neuron. 2005 Jun 2;46(5):693-4. PMID: 15924853

 

Zufall F. The TRPC2 ion channel and pheromone sensing in the accessory olfactory system. Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):245-50. PMID: 15871013

 

Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 3rd. Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Horm Behav. 2004 Dec;46(5):638-45. PMID: 15555506

 

Leinders-Zufall T, Brennan P, Widmayer P, S PC, Maul-Pavicic A, Jäger M, Li XH, Breer H, Zufall F, Boehm T. MHC class I peptides as chemosensory signals in the vomeronasal organ. Science. 2004 Nov 5;306(5698):1033-7. PMID: 15528444

 

Zufall F, Leinders-Zufall T (2004) Odor and pheromone transduction. In: Encyclopedia of Neuroscience, 3rd edition.  Eds. G. Adelman and B. H. Smith.  Elsevier Science, Amsterdam.

 

Lucas P, Ukhanov K, Leinders-Zufall T, Zufall F. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction.,Neuron. 2003 Oct 30;40(3):551-61. PMID: 14642279

 

Kelliher KR, Ziesmann J, Munger SD, Reed RR, Zufall F. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4299-304. PMID: 12649326

 

Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, Ogawa S, Zufall F, Mombaerts P. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature. 2002 Sep 5;419(6902):70-4. PMID: 12214233

 

Zufall F, Kelliher KR, Leinders-Zufall T. Pheromone detection by mammalian vomeronasal neurons. Microsc Res Tech. 2002 Aug 1;58(3):251-60. PMID: 12203702

 

Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R. Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6376-81. PMID: 1197203

 

Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau KW, Zufall F, Reed RR. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001 Dec 7;294(5549):2172-5. PMID: 11739959

 

Zufall F, Munger SD. From odor and pheromone transduction to the organization of the sense of smell. Trends Neurosci. 2001 Apr;24(4):191-3. PMID: 11249988

 

Zufall F, Leinders-Zufall T. The cellular and molecular basis of odor adaptation. Chem Senses. 2000 Aug;25(4):473-81. PMID: 10944513

 

Chen S, Lane AP, Bock R, Leinders-Zufall T, Zufall F. Blocking adenylyl cyclase inhibits olfactory generator currents induced by "IP(3)-odors". J Neurophysiol. 2000 Jul;84(1):575-80. PMID: 10899229

 

Leinders-Zufall T, Lane AP, Puche AC, Ma W, Novotny MV, Shipley MT, Zufall F. Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature. 2000 Jun 15;405(6788):792-6.  PMID: 10866200

 

Kafitz KW, Leinders-Zufall T, Zufall F, Greer CA. Cyclic GMP evoked calcium transients in olfactory receptor cell growth cones. Neuroreport. 2000 Mar 20;11(4):677-81. PMID: 10757499

 

Zufall F, Leinders-Zufall T, Greer CA. Amplification of odor-induced Ca(2+) transients by store-operated Ca(2+) release and its role in olfactory signal transduction. J Neurophysiol. 2000 Jan;83(1):501-12. PMID: 10634891

 

Leinders-Zufall T, Ma M, Zufall F. Impaired odor adaptation in olfactory receptor neurons after inhibition of Ca2+/calmodulin kinase II. J Neurosci. 1999 Jul 15;19(14):RC19. PMID: 10407061

 

Kingston PA, Zufall F, Barnstable CJ. Widespread expression of olfactory cyclic nucleotide-gated channel genes in rat brain: implications for neuronal signalling. Synapse. 1999 Apr;32(1):1-12. PMID: 10188632

 

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F. Visualizing odor detection in olfactory cilia by calcium imaging. Ann N Y Acad Sci. 1998 Nov 30;855:205-7. PMID: 9929606

 

Zufall F, Leinders-Zufall T. Role of cyclic GMP in olfactory transduction and adaptation. Ann N Y Acad Sci. 1998 Nov 30;855:199-204. PMID: 9929605

 

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F. Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction. J Neurosci. 1998 Aug 1;18(15):5630-9. PMID: 9671654

 

Zufall F, Shepherd GM, Barnstable CJ. Cyclic nucleotide gated channels as regulators of CNS development and plasticity. Curr Opin Neurobiol. 1997 Jun;7(3):404-12. PMID: 9232810

 

Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA, Zufall F. Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci. 1997 Jun 1;17(11):4136-48. PMID: 9151731

 

Zufall F, Leinders-Zufall T (1997) Olfactory Transduction. In: Encyclopedia of Neuroscience, 2nd edition (CD ROM), Adelman G and Smith BH (eds), Elsevier, Amsterdam, The Netherlands.

 

Zufall F, Leinders-Zufall T. Identification of a long-lasting form of odor adaptation that depends on the carbon Monoxide/cGMP second-messenger system. J Neurosci. 1997 Apr 15;17(8):2703-12. PMID: 9092591

 

Kingston PA, Zufall F, Barnstable CJ. Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10440-5. PMID: 8816819

 

Leinders-Zufall T, Shepherd GM, Zufall F. Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells. Proc Biol Sci. 1996 Jun 22;263(1371):803-11. PMID: 8763798

 

Leinders-Zufall T, Zufall F. Block of cyclic nucleotide-gated channels in salamander olfactory receptor neurons by the guanylyl cyclase inhibitor LY83583. J Neurophysiol. 1995 Dec;74(6):2759-62. PMID: 8747232

 

Leinders-Zufall T, Shepherd GM, Zufall F. Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol. 1995 Oct;74(4):1498-508. PMID: 8989388

 

Firestein S, Zufall F. The cyclic nucleotide gated channel of olfactory receptor neurons. Semin Cell Biol. 1994 Feb;5(1):39-46. PMID: 7514455

 

Zufall F, Firestein S, Shepherd GM. Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu Rev Biophys Biomol Struct. 1994;23:577-607. PMID: 7522666

 

Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan;12(1):155-65. PMID: 7507337

 

Zufall F, Hatt H, Firestein S. Rapid application and removal of second messengers to cyclic nucleotide-gated channels from olfactory epithelium. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9335-9. PMID: 7692446

 

Zufall F, Firestein S. Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons. J Neurophysiol. 1993 May;69(5):1758-68. PMID: 7685377

 

Firestein S, Zufall F. Membrane currents and mechanisms of olfactory transduction. Ciba Found Symp. 1993;179:115-26; discussion 126-30, 147-9. PMID: 8168373

 

Zufall F. Cyclic AMP-gated cation channels of olfactory receptor neurons. EXS. 1993;66:135-45. Review. PMID: 7505646

 

Stengl M, Zufall F, Hatt H, Hildebrand JG. Olfactory receptor neurons from antennae of developing male Manduca sexta respond to components of the species-specific sex pheromone in vitro. J Neurosci. 1992 Jul;12(7):2523-31. PMID: 1377232

 

Bufler J, Zufall F, Franke C, Hatt H. Patch-clamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: GABA- and other transmitter receptors. J Comp Physiol [A]. 1992 Feb;170(2):153-9. PMID: 1374799

 

Bufler J, Zufall F, Franke C, Hatt H. Patch-clamp recordings of spiking and nonspiking interneurons from rabbit olfactory bulb slices: membrane properties and ionic currents. J Comp Physiol [A]. 1992 Feb;170(2):145-52. PMID: 1374798

 

Zufall F, Shepherd GM, Firestein S. Inhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calcium. Proc Biol Sci. 1991 Dec 23;246(1317):225-30. PMID: 1686087

 

Zufall F, Firestein S, Shepherd GM. Analysis of single cyclic nucleotide-gated channels in olfactory receptor cells. J Neurosci. 1991 Nov;11(11):3573-80. PMID: 1719166

 

Firestein S, Zufall F, Shepherd GM. Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides. J Neurosci. 1991 Nov;11(11):3565-72. PMID: 1719165

 

Smith DO, Franke C, Rosenheimer JL, Zufall F, Hatt H. Desensitization and resensitization rates of glutamate-activated channels may regulate motoneuron excitability. J Neurophysiol. 1991 Oct;66(4):1166-75. PMID: 1722243

 

Zufall F, Hatt H. Dual activation of a sex pheromone-dependent ion channel from insect olfactory dendrites by protein kinase C activators and cyclic GMP. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8520-4. PMID: 1717980

 

Smith DO, Franke C, Rosenheimer JL, Zufall F, Hatt H. Glutamate-activated channels in adult rat ventral spinal cord cells. J Neurophysiol. 1991 Aug;66(2):369-78. PMID: 1723092

 

Zufall F, Stengl M, Franke C, Hildebrand JG, Hatt H. Ionic currents of cultured olfactory receptor neurons from antennae of male Manduca sexta. J Neurosci. 1991 Apr;11(4):956-65. PMID: 1849175

 

Zufall F, Franke C, Hatt H. Similarities between the effects of lindane (gamma-HCH) and picrotoxin on ligand-gated chloride channels in crayfish muscle membrane. Brain Res. 1989 Dec 4;503(2):342-5. PMID: 2481565

 

Zufall F, Schmitt M, Menzel R. Spectral and polarized light sensitivity of photoreceptors in the compound eye of the cricket (Gryllus bimaculatus). J Comp Physiol [A]. 1989 Feb;164(5):597-608. PMID: 2709343